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clinical evidence for its utility in treatment of invasive disease caused by fusarium species (fusariosis) is limited.
it appears to be helpful in a mouse model of naegleriasis.
oritavancin, sold under the brand name orbactiv, is a novel semisynthetic glycopeptide antibiotic medication for the treatment of serious gram-positive bacterial infections. its chemical structure as a lipoglycopeptide is similar to vancomycin.
the u.s. food and drug administration (fda) and the european medicines agency (ema) have approved oritavancin for treatment of acute bacterial skin and skin structure infections.
in vitro activity oritavancin shares certain properties with other members of the glycopeptide class of antibiotics, which includes vancomycin, the current standard of care for serious gram-positive infections in the united states and europe. it possesses potent and rapid bactericidal activity in vitro against a broad spectrum of both resistant and susceptible gram-positive bacteria, including staphylococcus aureus, mrsa, enterococci, and streptococci. oritavancin was more active than either metronidazole or vancomycin against strains of clostridium difficile tested.
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common side effect include low blood cell counts and vomiting. other side effects include tiredness and depression. it is not recommended in people with severe liver or kidney problems. use in pregnancy is known to harm the baby. procarbazine is in the alkylating agents family of medication. how it works is not clearly known.
procarbazine was approved for medical use in the united states in 1969. it is on the world health organization’s list of essential medicines, the safest and most effective medicines needed in a health system. in the united kingdom a month of treatment cost the nhs 450 to 750 pounds.
medical uses when used to treat hodgkin’s lymphoma, it is often delivered as part of the beacopp regimen that includes bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine (tradename oncovin), prednisone, and procarbazine. the first combination chemotherapy developed for hodgkin’s lymphoma (hl), mopp also included procarbazine (abvd has supplanted mopp as standard first line treatment for hl, with beacopp as an alternative for advanced/unfavorable hl). alternatively, when used to treat certain brain tumors (malignant gliomas), it is often dosed as pcv when combined with lomustine (often called ccnu) and vincristine.
dose should be adjusted for kidney disease or liver disease.
side effects very common (greater than 10% of people experience them) adverse effects include loss of appetite, nausea and vomiting. other side effects of unknown frequency include reduction in leukocytes, reduction in platelets, reduction in neutrophils, which can lead to increased infections including lung infections; severe allergy-like reactions that can lead to angioedema and skin reactions; lethargy; liver complications including jaundice and abnormal liver function tests; reproductive effects including reduction in sperm count and ovarian failure.
when combined with ethanol, procarbazine may cause a disulfiram-like reaction in some people.
it weakly inhibits mao in the gastrointestinal system, so it can cause hypertensive crises if associated with the ingestion of tyramine-rich foods such as aged cheeses; this appears to be rare.
procarbazine rarely causes chemotherapy-induced peripheral neuropathy, a progressive, enduring, often irreversible tingling numbness, intense pain, and hypersensitivity to cold, beginning in the hands and feet and sometimes involving the arms and legs.
doxorubicin , sold under the brand name adriamycin among others, is a chemotherapy medication used to treat cancer. this includes breast cancer, bladder cancer, kaposi’s sarcoma, lymphoma, and acute lymphocytic leukemia. it is often used together with other chemotherapy agents. doxorubicin is given by injection into a vein.
common side effects include hair loss, bone marrow suppression, vomiting, rash, and inflammation of the mouth. other serious side effects may include allergic reactions such as anaphylaxis, heart damage, tissue damage at the site of injection, radiation recall, and treatment-related leukemia. people often experience red discoloration of the urine for a few days. doxorubicin is in the anthracycline and antitumor antibiotic family of medications. it works in part by interfering with the function of dna.
doxorubicin was approved for medical use in the united states in 1974. it is on the world health organization’s list of essential medicines. versions that are pegylated and in liposomes are also available; however, are more expensive. doxorubicin was originally made from the bacterium streptomyces peucetius.
medical use doxorubicin is commonly used to treat some leukemias and hodgkin’s lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma, multiple myeloma, and others. commonly used doxorubicin-containing regimens are ac (adriamycin, cyclophosphamide), tac (taxotere, ac), abvd (adriamycin, bleomycin, vinblastine, dacarbazine), beacopp, chop (cyclophosphamide, hydroxydaunorubicin, vincristine, prednisone) and fac (5-fluorouracil, adriamycin, cyclophosphamide).
doxil (see below) is used primarily for the treatment of ovarian cancer where the disease has progressed or recurred after platinum-based chemotherapy, or for the treatment of aids-related kaposi’s sarcoma.
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posaconazole, sold under the brand names noxafil and posanol is a triazole antifungal medication.
it was approved for medical use in the united states in september 2006, and is available as a generic medication.
medical uses
posaconazole is used to treat invasive aspergillus and candida and fungal infections caused by scedosporium and fusarium species, which may occur in immunocompromised patients. it is also used for the treatment of oropharyngeal candidiasis (opc), including opc refractory to itraconazole and/or fluconazole therapy.
it is also used to treat invasive infections by candida, mucor, and aspergillus species in severely immunocompromised patients.
clinical evidence for its utility in treatment of invasive disease caused by fusarium species (fusariosis) is limited.
it appears to be helpful in a mouse model of naegleriasis.
oritavancin, sold under the brand name orbactiv, is a novel semisynthetic glycopeptide antibiotic medication for the treatment of serious gram-positive bacterial infections. its chemical structure as a lipoglycopeptide is similar to vancomycin.
the u.s. food and drug administration (fda) and the european medicines agency (ema) have approved oritavancin for treatment of acute bacterial skin and skin structure infections.
in vitro activity
oritavancin shares certain properties with other members of the glycopeptide class of antibiotics, which includes vancomycin, the current standard of care for serious gram-positive infections in the united states and europe. it possesses potent and rapid bactericidal activity in vitro against a broad spectrum of both resistant and susceptible gram-positive bacteria, including staphylococcus aureus, mrsa, enterococci, and streptococci. oritavancin was more active than either metronidazole or vancomycin against strains of clostridium difficile tested.
oritavancin has potential use as a therapy for exposure to bacillus anthracis, the gram-positive bacterium that causes anthrax, having demonstrated efficacy in a mouse model both before and after exposure to the bacterium.
mechanism
the 4′-chlorobiphenylmethyl group disrupts the cell membrane of gram-positive bacteria. it also acts by inhibition of transglycosylation and inhibition of transpeptidation.
procarbazine is a chemotherapy medication used for the treatment of hodgkin’s lymphoma and brain cancers. for hodgkin’s it is often used together with chlormethine, vincristine, and prednisone while for brain cancers such as glioblastoma multiforme it is used with lomustine and vincristine. it is typically taken by mouth.
common side effect include low blood cell counts and vomiting. other side effects include tiredness and depression. it is not recommended in people with severe liver or kidney problems. use in pregnancy is known to harm the baby. procarbazine is in the alkylating agents family of medication. how it works is not clearly known.
procarbazine was approved for medical use in the united states in 1969. it is on the world health organization’s list of essential medicines, the safest and most effective medicines needed in a health system. in the united kingdom a month of treatment cost the nhs 450 to 750 pounds.
medical uses
when used to treat hodgkin’s lymphoma, it is often delivered as part of the beacopp regimen that includes bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine (tradename oncovin), prednisone, and procarbazine. the first combination chemotherapy developed for hodgkin’s lymphoma (hl), mopp also included procarbazine (abvd has supplanted mopp as standard first line treatment for hl, with beacopp as an alternative for advanced/unfavorable hl). alternatively, when used to treat certain brain tumors (malignant gliomas), it is often dosed as pcv when combined with lomustine (often called ccnu) and vincristine.
dose should be adjusted for kidney disease or liver disease.
side effects
very common (greater than 10% of people experience them) adverse effects include loss of appetite, nausea and vomiting. other side effects of unknown frequency include reduction in leukocytes, reduction in platelets, reduction in neutrophils, which can lead to increased infections including lung infections; severe allergy-like reactions that can lead to angioedema and skin reactions; lethargy; liver complications including jaundice and abnormal liver function tests; reproductive effects including reduction in sperm count and ovarian failure.
when combined with ethanol, procarbazine may cause a disulfiram-like reaction in some people.
it weakly inhibits mao in the gastrointestinal system, so it can cause hypertensive crises if associated with the ingestion of tyramine-rich foods such as aged cheeses; this appears to be rare.
procarbazine rarely causes chemotherapy-induced peripheral neuropathy, a progressive, enduring, often irreversible tingling numbness, intense pain, and hypersensitivity to cold, beginning in the hands and feet and sometimes involving the arms and legs.
doxorubicin , sold under the brand name adriamycin among others, is a chemotherapy medication used to treat cancer. this includes breast cancer, bladder cancer, kaposi’s sarcoma, lymphoma, and acute lymphocytic leukemia. it is often used together with other chemotherapy agents. doxorubicin is given by injection into a vein.
common side effects include hair loss, bone marrow suppression, vomiting, rash, and inflammation of the mouth. other serious side effects may include allergic reactions such as anaphylaxis, heart damage, tissue damage at the site of injection, radiation recall, and treatment-related leukemia. people often experience red discoloration of the urine for a few days. doxorubicin is in the anthracycline and antitumor antibiotic family of medications. it works in part by interfering with the function of dna.
doxorubicin was approved for medical use in the united states in 1974. it is on the world health organization’s list of essential medicines. versions that are pegylated and in liposomes are also available; however, are more expensive. doxorubicin was originally made from the bacterium streptomyces peucetius.
medical use
doxorubicin is commonly used to treat some leukemias and hodgkin’s lymphoma, as well as cancers of the bladder, breast, stomach, lung, ovaries, thyroid, soft tissue sarcoma, multiple myeloma, and others. commonly used doxorubicin-containing regimens are ac (adriamycin, cyclophosphamide), tac (taxotere, ac), abvd (adriamycin, bleomycin, vinblastine, dacarbazine), beacopp, chop (cyclophosphamide, hydroxydaunorubicin, vincristine, prednisone) and fac (5-fluorouracil, adriamycin, cyclophosphamide).
doxil (see below) is used primarily for the treatment of ovarian cancer where the disease has progressed or recurred after platinum-based chemotherapy, or for the treatment of aids-related kaposi’s sarcoma.
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